In vitro and in vivo investigation of dendronized streptavidin and fluorescent nanodiamonds, two flexible nanosystems efficiently crossing the blood-brain barrier to improve nanotheranostics in neurological disease treatment

Pierpaolo Moscariello
In treatment of central nervous system (CNS) diseases, the blood-brain barrier (BBB) is the main obstacle preventing drug molecule penetration from the bloodstream into the brain. In this thesis dendronized streptavidin (DSA) and fluorescent nanodiamonds (fNDs) encapsulated by a human serum albumin (HSA)-based biopolymer (dcHSA-fNDs) are presented as promising platforms for treatment of neurological disorders via crossing an intact BBB. DSA provides a flexible bio-click system composed of an adapter of tetrameric streptavidin linked to...
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