Analysis of Neil DNA glycosylases during early Xenopus development

Dandan Han
DNA demethylation plays an important role in development and vertebrate physiology. In active DNA demethylation, 5-methylcytosine (5mC) is iteratively oxidized into 5-hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-caboxylcytosine (5caC) by Ten-eleven-translocation (TET) enzymes. Subsequently, 5fC and 5caC are removed by Thymine DNA glycosylase (TDG) and base excision repair (BER) proteins. In vitro data indicate that Nei-like (NEIL) glycosylases play a crucial role in this context by increasing the enzymatic turnover of TDG in BER. In the...
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