Modulation of intrahepatic immune responses through nanoparticle-mediated delivery of drugs, adjuvants, and antigens

Michael Fichter
Targeted delivery of drugs, antigens, or adjuvants to organs and cells of interest is a promising concept for the development of novel drug or vaccine formulations. Polymeric nanocapsules are particularly suited for the application as vaccine delivery systems, since they facilitate combined delivery of antigens along with adjuvants to antigen-presenting cells (APCs). Intravenous administration of these nanocarriers enables targeting of liver APCs inducing intrahepatic T cellular immune responses essential for eradication of viral infections, e.g....
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