Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage

Axel Neulen, Tobias Pantel, Michael Kosterhon, Andreas Kramer, Sascha Kunath, Maximilian Petermeyer, Bernd Moosmann, Johannes Lotz, Sven Rainer Kantelhardt, Florian Ringel & Serge Thal
Cerebral hypoperfusion in the first hours after subarachnoid haemorrhage (SAH) is a major determinant of poor neurological outcome. However, the underlying pathophysiology is only partly understood. Here we induced neutropenia in C57BL/6N mice by anti-Ly6G antibody injection, induced SAH by endovascular filament perforation, and analysed cerebral cortical perfusion with laser SPECKLE contrast imaging to investigate the role of neutrophils in mediating cerebral hypoperfusion during the first 24 h post-SAH. SAH induction significantly increased the intracranial...
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