IL-4 receptor alpha signaling through macrophages differentially regulates liver fibrosis progression and reversal

Shih-Yen Weng, Xiaoyu Wang, Santosh Vijayan, Yilang Tang, Yong Ook Kim, Kornelius Padberg, Tommy Regen, Olena Molokanova, Tao Chen, Tobias Bopp, Hansjörg Schild, Frank Brombacher, Jeff R. Crosby, Michael L. McCaleb, Ari Waisman, Ernesto Bockamp & Detlef Schuppan
Chronic hepatitis leads to liver fibrosis and cirrhosis. Cirrhosis is a major cause ofworldwide morbidity and mortality. Macrophages play a key role in fibrosis progression and reversal. However, the signals that determine fibrogenic vs fibrolytic macrophage function remain ill defined. We studied the role of interleukin-4 receptor α (IL-4Rα), a potential central switch of macrophage polarization, in liver fibrosis progression and reversal. We demonstrate that inflammatory monocyte infiltration and liver fibrogenesis were suppressed in general...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.