Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis

Avinash Khandagale, Jens M. Kittner, Amrit Mann, Stefanie Ascher, Bettina Kollar & Christoph Reinhardt
Patients with inflammatory bowel disease (IBD) are susceptible to thromboembolism. Interestingly, IBD occurs less frequently in patients with inherited bleeding disorders. Therefore, we analyzed whether F9-deficiency is protective against the onset of acute colitis in a genetic hemophilia B mouse model. In the 3.5% dextran sulfate sodium (DSS)-induced colitis model, F9 deficient mice were protected from body-weight loss and had a reduced disease activity score. We detected decreased colonic myeloperoxidase activity and decreased CXCL1 levels...
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