Giant depolarizing potentials trigger transient changes in the intracellular Cl(-) concentration in CA3 pyramidal neurons of the immature mouse hippocampus

Peter Jedlicka, Aniello Lombardi, Heiko Luhmann & Werner Kilb
Giant depolarizing potentials (GDPs) represent a typical spontaneous activity pattern in the immature hippocampus. GDPs are mediated by GABAergic and glutamatergic synaptic inputs and their initiation requires an excitatory GABAergic action, which is typical for immature neurons due to their elevated intracellular Cl(-) concentration ([Cl(-)](i)). Because GABA(A) receptors are ligand gated Cl(-) channels, activation of these receptors can potentially influence [Cl(-)](i). However, whether the GABAergic activity during GDPs influences [Cl(-)](i) is unclear. To address this...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.