Understanding and predicting antidepressant response : using animal models to move toward precision psychiatry

David P. Herzog, Holger Beckmann, Klaus Lieb, Soojin Ryu & Marianne B. Müller
There are two important gaps of knowledge in depression treatment, namely the lack of biomarkers predicting response to antidepressants and the limited knowledge of the molecular mechanisms underlying clinical improvement. However, individually tailored treatment strategies and individualized prescription are greatly needed given the huge socio-economic burden of depression, the latency until clinical improvement can be observed and the response variability to a particular compound. Still, individual patient-level antidepressant treatment outcomes are highly unpredictable. In contrast...
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