Induction of interleukin 10-producing : nonproliferating Cd4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

Helmut Jonuleit, Edgar Schmitt, Gerold Schuler, Jürgen Knop & Alexander Enk
The functional properties of dendritic cells (DCs) are strictly dependent on their maturational state. To analyze the influence of the maturational state of DCs on priming and differentiation of T cells, immature CD83− and mature CD83+ human DCs were used for stimulation of naive, allogeneic CD4+ T cells. Repetitive stimulation with mature DCs resulted in a strong expansion of alloreactive T cells and the exclusive development of T helper type 1 (Th1) cells. In contrast,...
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