Physical exercise induces rapid release of small extracellular vesicles into the circulation

Carsten Frühbeis, Susanne Helmig, Suzan Tug, Perikles Simon & Eva-Maria Albers
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and...
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