Proteomic characterization of the biomolecular corona and its impact on cellular uptake

Johanna Simon
Once nanoparticles are exposed to a biological milieu, blood components rapidly interact with the nanoparticles´ surface, hereby giving the nanoparticle a biological fingerprint (´biomolecular corona´). This process determinately affects the pharmacological profile and therapeutic efficiency of any nanoparticle. Despite the great effort in the development of nanoparticles with a protein-repellent surface (for example surface functionalization with PEG), it is still under debate whether it is possible to completely prevent protein adsorption. Therefore, a thorough characterization...
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