Regulation and cell-to-cell variability of estrogen-dependent transcription

Christoph Alexander Fritzsch
Transcription is the major control point for the production of cellular components, and as such, it governs fate and function of cells. Surprisingly, this critical step in information transmission is rather unreliable: The low copy-number of molecules controlling transcription, leads to stochastic effects in the production of RNAs. Discontinuities in transcriptional permissiveness of gene promoters, witnessed as “transcriptional bursts”, amplify this effect and lead to variability in gene expression between cells. Furthermore, the cellular state...
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