The epigenetic landscape of the heart in ischemia-reperfusion injury

Ina Caroline Kirmes
Ischemic heart diseases are the leading cause of death worldwide. Cardiomyocytes detect and adapt to hypoxic and nutritional stress through immediate transcriptional, translational and metabolic responses. The environmental effects of ischemia on chromatin nanostructure were analysed by characterising and integrating chromatin structure with differential gene expression analysis. Short-term oxygen and nutrient deprivation (OND) of the cardiomyocyte cell-line HL-1 induces a previously undescribed chromatin architecture, consisting of large, chromatin sparse voids interspersed between ring-like structures. Along...
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