Molecular mechanism of action and pharmacogenomics of curcumin, curcumin synthetic derivatives and combinations with curcumin in cancer therapy

Edna Ooko
Curcumin has been shown to be active against various cancers and it has also been seen to exhibit good synergism with other nutraceutical for example resveratrol, piperine and genistein. In this study we have investigated nineteen new synthetic derivatives of curcumin for their anticancer activity and further assessed the effect on cancer cells of a combination of curcumin and ascorbic acid (AA). The first part of this work focused on overcoming multidrug resistance and the...
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