Cutting edge : a key pathogenic role of IL-27 in T cell-mediated hepatitis

Jürgen Siebler, Stefan Wirtz, Christian Frenzel, Marcus Schuchmann, Ansgar W. Lohse, Peter R. Galle & Markus F. Neurath
The signals driving T cell activation in T cell-mediated fulminant hepatitis are not fully understood. In this study, we identify the cytokine IL-27p28/EBI3 as a major pathogenic factor in the ConA model of T cell-mediated hepatitis. We found an up-regulation of hepatic EBI3 and p28 expression and augmented levels of IL-27 in wild-type mice after ConA administration, suggesting a potential pathogenic role of this cytokine in ConA hepatitis. Consistently, IL-27 EBI3-deficient mice were almost completely...
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