The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

Almut Dufner, Agnes Kisser, Sandra Niendorf, Anja Basters, Sonja Reissig, Anne Schönle, Annette Aichem, Thorsten Kurz, Andreas Schlosser, Deborah Yablonski, Marcus Groettrup, Thorsten Buch, Ari Waisman, Wolfgang W. Schamel, Marco Prinz & Klaus-Peter Knobeloch
The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3[beta]. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in mice...
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