The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

Markus F. Neurath, Benno Weigmann, Susetta Finotto, Jonathan Glickman, Edward E. Nieuwenhuis, Hideki Iijima, A. Mizoguchi, E. Mizoguchi, Jonas Mudter, Peter R. Galle, A. Bhan, Frank Autschbach, B. M. Sullivan, S. J. Szabo, Laurie H. Glimcher & Richard S. Blumberg
The balance between pro and antiinflammatory cytokines secreted by T cells regulates both the initiation and perpetuation of inflammatory bowel diseases (IBD). In particular, the balance between interferon (IFN)-gamma/interleukin (IL)-4 and transforming growth factor (TGF)-beta activity controls chronic intestinal inflammation. However, the molecular pathways that evoke these responses are not well understood. Here, we describe a critical role for the transcription factor T-bet in controlling the mucosal cytokine balance and clinical disease. We studied the...
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