Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

Susetta Finotto, Markus F. Neurath, Jonathan N. Glickman, Shixin Qin, Hans-Anton Lehr, Francis H. Y. Green, Kate Ackerman, Kathleen Haley, Peter R. Galle, Susanne J. Szabo, Jeffrey M. Drazen, George T. De Sanctis & Laurie H. Glimcher
Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4 cells from T-bet knockout mice spontaneously...
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