Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression

Susetta Finotto, George T. De Sanctis, Hans-Anton Lehr, Udo Herz, Michael Buerke, Mechthild Schipp, Brigitte Bartsch, Raja Atreya, Edgar Schmitt, Peter R. Galle, Harald Renz & Markus F. Neurath
Recent studies in transgenic mice have revealed that expression of a dominant negative form of the transcription factor GATA-3 in T cells can prevent T helper cell type 2 (Th2)-mediated allergic airway inflammation in mice. However, it remains unclear whether GATA-3 plays a role in the effector phase of allergic airway inflammation and whether antagonizing the expression and/or function of GATA-3 can be used for the therapy of allergic airway inflammation and hyperresponsiveness. Here, we...
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