Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question

Markus F. Neurath, Susetta Finotto, Ivan Fuss, Monica Boirivant, Peter R. Galle & Warren Strober
T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.
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