Immunotherapy of inflammatory bowel diseases: current concepts and future perspectives

Markus F. Neurath
The etiology and the pathogenesis of inflammatory bowel diseases (IBD), e.g. Crohn\'s disease and ulcerative colitis are still not completely understood. However, there is growing evidence that an alteration of the mucosal immune system towards luminal antigens in a genetically susceptible host plays a key role in the pathogenesis of IBD. In particular, cytokines produced by intestinal epithelial cells, lamina propria macrophages and CD4+ T cells appear to contribute to the initiation and perpetuation of...
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