Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice

Ivan J. Fuss, Thomas Marth, Markus F. Neurath, Glen R. Pearlstein, Ashish Jain & Warren Strober
BACKGROUND & AIMS: Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS: Cells and tissue from mice with TNBS colitis receiving treatment with anticytokines were analyzed for phenotype, cytokine production, and apoptosis. RESULTS: In initial studies, we found that treatment of mice with TNBS-induced colitis with anti-IL-12 was more...
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