RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

Marion A. Hofmann, Steven Drury, Caifeng Fu, Wu Qu, Akihiko Taguchi, Yan Lu, Cecilia Avila, Neeraja Kambham, Angelika Bierhaus, Peter Nawroth, Markus F. Neurath, Timothy Slattery, Dale Beach, John McClary, Mariko Nagashima, John Morser, David M. Stern & Ann Marie Schmidt
S100/calgranulin polypeptides are present at sites of inflammation, likely released by inflammatory cells targeted to such loci by a range of environmental cues. We report here that receptor for AGE (RAGE) is a central cell surface receptor for EN-RAGE (extracellular newly identified RAGE-binding protein) and related members of the S100/calgranulin superfamily. Interaction of EN-RAGEs with cellular RAGE on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Blockade of EN-RAGE/RAGE...
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