Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

Markus F. Neurath, Ivan J. Fuss, Manolis Pasparakis, Lena Alexopoulou, Sylva Haralambous, Karl-Hermann Meyer Zum Büschenfelde, Warren Strober & George Kollias
Antibodies to tumor necrosis factor (TNF)-alpha have been recently proposed as effective treatment for patients with Crohn's disease. Here, we analyze the functional role of TNF-alpha in a mouse model of chronic intestinal inflammation induced by the hapten reagent 2,4,6,-trinitrobenzene sulfonic acid (TNBS) that mimics some characteristics of Crohn's disease in humans. Macrophage-enriched lamina propria (LP) mononuclear cells from mice with TNBS-induced colitis produced 10-30-fold higher levels of TNF-alpha mRNA and protein than cells from...
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