Towards the Synthesis of Amphidinolides C, F and U

Constantina Pyrkotis
The amphidinolides are a family of structurally-related cytotoxic natural products which have shown powerful antitumour activity against murine lymphoma (LI210), human epidermoid carcinoma (KB) and human colon tumor cells (HCT116). They occur naturally in only minute amounts, in specific strains of the microscopic marine dinoflagellate amphidinium sp. Total synthesis therefore becomes an important potential source of these natural products. Chapter One presents the amphidinolide family and specifically the isolation, structural features, biosynthesis and elucidation of...
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