Cholesterol, racial variation and targeted medicines

Eric J Topol
Only a year or so ago we thought we understood the primary determinants of low-density lipoprotein, 'bad' cholesterol in the bloodstream--apolipoprotein B and the LDL receptor. But since 2003, a flurry of human genetic studies have emphasized a new player, the gene encoding proprotein convertase subtilisin/kexin type 9, PCSK9. Abifadel and colleagues identified two missense mutations in PCSK9 to account for a form of autosomal dominant hypercholesterolemia in French families1. Soon thereafter, a third missense...
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