Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities

Nicole Frahm, BT Korber, CM Adams, JJ Szinger, R Draenert, MM Addo, ME Feeney, K Yusim, K Sango, NV Brown, D SenGupta, A Piechocka-Trocha, T Simonis, FM Marincola, AG Wurcel, Stone, DR, CJ Russell, P Adolf, D Cohen, T Roach, A StJohn, A Khatri, K Davis, J Mullins, PJR Goulder … & C Brander
Although there is increasing evidence that virus-specific cytotoxic-T-lymphocyte (CTL) responses play an important role in the control of human immunodeficiency virus (HIV) replication in vivo, only scarce CTL data are available for the ethnic populations currently most affected by the epidemic. In this study, we examined the CD8+-T-cell responses in African-American, Caucasian, Hispanic, and Caribbean populations in which clade B virus dominates and analyzed the potential factors influencing immune recognition. Total HIV-specific CD8+-T-cell responses were...
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