The Role of Caspase-2 and PIDD1 in Lung Tumorigenesis and Response to Genotoxic Stress

Matthew Robinson Terry
Platinum-based chemotherapy is the standard-of-care for non-small cell lung cancer. As with other chemotherapies, not all patients respond positively to treatment and almost all patients will develop chemotherapy-resistant disease. Using the KrasG12D-driven mouse model of lung adenocarcinoma, our lab identified upregulation of p53-induced with a death domain isoform 1 (Pidd1) in resistant tumors in response to long-term cisplatin chemotherapy treatment. Remarkably, PIDD1 expression in vitro induces p53-dependent resistance to cisplatin as well as other DNA,...
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