Retroviral Capsid Recognition by the Host Restriction Factor TRIM5 Alpha

Viswanathan Chandrasekaran
Mammalian hosts have evolved protein "restriction factors" to combat retroviruses. TRIM5α and the related TRIMCyp protein (collectively TRIM5), are restriction factors that can potently restrict retroviruses, including HIV-1, by binding their capsids and blocking reverse transcription. Previous studies have shown that the C-terminal SPRY/CypA domains of TRIM5 proteins bind the capsids of susceptible retroviruses and that higher-order oligomerization of TRIM5 proteins apparently also contributes to capsid binding. However, the biochemical and structural details of these...
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