Modeling Clear Cell Sarcomagenesis

Krystal M. Straessler
Clear cell sarcoma (CCS) is a rare but devastating malignancy with a proclivity for young adults, disturbingly low survivability, and recalcitrance to therapies. Due to the low incidence, it remains difficult to investigate the mechanism behind CCS. By generating an accurate model system that recapitulates human tumor dynamics, there is hope that the molecular mechanisms required for tumor initiation and maintenance can be identified and lead to more directed, successful therapeutic options. CCS achieves its...
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