Organization of mitochondrial membranes upon oxidative stress: Impact on apoptosis regulating protein-lipid interactions of Bcl-2 proteins

Professor Gerhard Groebner, Dr Hanna Wacklin-Knecht, Dr Luke Clifton, Dr Arwel Hughes, Dr Jörgen Ådén, Mr Artur Dingeldein & Dr Mario Campana
Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a major regulator in mammalian cells death, where pro- and anti-survival Bcl-2 proteins meet at the mitochondrial outer membrane and tightly regulate the fate of a cell. Treatment-resistant tumour cells often possess mitochondria which are enriched in the pro-survival Bcl-2 membrane protein which blocks any apoptotic signals upon onset...
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