Adsorption of NHE1 intracellular domain on lipid bilayers

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Recently the intracellular domain (ICD ) of the Na+/H+ exchanger isoform 1 (NHE1), is a transmembrane protein, has been identified as an intrinsically disordered protein. NHE1/ICD regulates protein activity via binding of other proteins, kinases or calmodulin, as well as by interacting with the anionic phospholipids in the membrane. Although a specific lipid interaction domain (LID) in NHE1/ICD (named here after NHE1/LID) was identified, a detailed picture of the mechanism of interaction between the lipids...
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