Molecular interactions in amorphous paracetamol

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The appearance of multiple crystal forms is one of the bottlenecks in pharmaceutical formulation. To date the result of a crystallisation experiment cannot be predicted and we do not understand the influence of the amorphous phase (solution or melt) on the crystal form. A lot of attention has been paid to crystallisation from solution, which is currently the standard method in industry, whilst crystallisation from the melt has been widely neglected. However, this crystallisation pathway...
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