Ceramide conformational thermotropic behaviour within the skin¿s long periodicity phase

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The stratum corneum layer of the skin acts as a barrier between the body and the external environment. This is achieved by corneocytes encased in a lamellar lipid matrix, which provides the only continuous pathway through the barrier. Skin diseases occur primarily due to alterations in the lipid matrix, which in turn compromises the lipid packing and the barrier capability. One common alteration is a decrease in lateral packing density, which can encourage lipids to...
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