Effect of Cholesterol on NHE1 intracellular domain adsorption on lipid bilayers

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The Na+/H+ exchanger isoform 1 (NHE1) is a transmembrane protein with the primary function of regulating the pH in the cytosol by exchanging one proton with one Na+ ion. The NHE1 intracellular domain (ICD) is an intersically disordered proteins which regulates protein activity via binding of other proteins, as well as by interacting with the anionic phospholipids in the membrane. Although a specific lipid interaction domain (LID) in NHE1/ICD (named here after NHE1/LID) was identified,...
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