Unravelling the thermal denaturation and stability of the solution structures of industrially-important antibodies with and without glycans

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The glycosylation of glycoproteins is a major determinant of their stability, and glycans also affect their aggregatibility (precipitation). An understanding of this is essential for improving manufacturing processes. Our extensive background in glycosylation and scattering (see below) indicates that we are ideally positioned to investigate antibody glycan structures in detail. Our overall aim is to identify how the solution properties of glycans affect antibody manufacture. Following our successful comparison of glycosylated and deglycosylated IgG antibodies...
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