Effects of rapamycin on chromatin – implications for ageing and tumour suppression

Field Adam
The role of mTORC1 in ageing is well established, with reduction in mTORC1 associated signalling being an accepted longevity assurance mechanism. Rapamycin, a potent inhibitor of mTORC1, has been shown to extend lifespan in a range of models, inhibit tumorigenesis and ameliorate symptoms of age associated decline. Rapamycin has been shown to prevent age associated epigenetic change on histones (Gong et al., 2015) and DNA methylation (Cole et al., 2017; Wang et al., 2017). However,...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.