Changes in brain anatomy during the course of PTSD

Valerie Cardenas, Kristin Samuelson, Maryanne A. Lenoci, Colin Studholme, Thomas C. Neylan, Charles R. Marmar, Norbert Schuff & Michael W. Weiner
Longitudinal structural T1-weighted images from middle-aged controls and veterans with PTSD (post-traumatic stress disorder). Most patients were Vietnam veterans. The goal of this study was to determine whether PTSD was associated with an increase in time-related decline in macrostructural brain volume and whether these changes were associated with accelerated cognitive decline. To quantify brain structure, 3 dimensional T1-weighted MRI scans were performed at baseline and again after a minimum of 24 months in 25 patients...
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