CSF Biomarker and PIB-PET Derived Beta-Amyloid Signature Predicts Metabolic, Grey Matter and Cognitive Changes in Non-Demented Subjects

Michael Ewers, Philip Insel, William J. Jagust, Leslie Shaw, John Q. Trojanowski, Paul Aisen, Ronald C. Petersen, Norbert Schuff & Michael W. Weiner
Beta-amyloid (Aß is a histopathological hallmark of Alzheimer's disease dementia, but high levels of Aß in the brain can also be found in a substantial proportion of nondemented subjects. Here we investigated which 2-year rate of brain and cognitive changes are present in nondemented subjects with high and low Aß levels, as assessed with cerebrospinal fluid and molecular positron emission tomography (PET)-based biomarkers of Aß. In subjects with mild cognitive impairment, increased brain Aß levels...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.