White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI

Yu Zhang, Norbert Schuff, An-Tao Du, Howard J. Rosen, Joel H. Kramer, Maria Luisa Gorno-Tempini, Bruce L. Miller, Michael W. Weiner &
Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging (DTI) measurements of fractional anisotropy (FA) can be useful in distinguishing the different patterns of white matter degradation between the two dementias. In this study, we performed MRI scans in a 4 Tesla MRI machine including T1-weighted structural images and diffusion tensor images in 18 patients with FTD, 18 patients with Alzheimer's disease and 19...
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