Remineralization of dentin, Effect of Protease Inhibitors

Stefan Habelitz, Grayson Marshall & Hamid Nurrohman
Mineralized and sound dentin matrices contain inactive preforms of proteolytic enzymes that may be activated during the demineralization cycle. In this study, we tested the hypothesis that protease inhibitors (PI) preserve demineralized collagen fibrils and other constituents of the dentin matrix and thereby affect the potential for remineralization. Artificial carious lesions with lesion depths of 140 µm were created with acetate buffer (pH=5.0, 66 hours), and remineralized using a polymer-induced-liquid-precursor (PILP) process (pH=7.4, 14 days)...
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