Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis.

Yu Zhang, An-Tao Du, Satoru Hayasaka, Geon-Ho Jahng, Jennifer Hlavin, Wang Zhan, Michael W. Weiner, Norbert Schuff & Memory And Aging Center
In diffusion tensor imaging (DTI), interpreting changes in terms of fractional anisotropy (FA) and mean diffusivity or axial (D(||)) and radial (D(?)) diffusivity can be ambiguous. The main objective of this study was to gain insight into the heterogeneity of age-related diffusion changes in human brain white matter by analyzing relationships between the diffusion measures in terms of concordance and discordance instead of evaluating them separately, which is difficult to interpret. Fifty-one cognitively normal subjects...
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