Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes

Benedikt Hallgrimsson, Charles Roseman, James Cheverud, Jennifer Fish, Ralph Marcucio, Rebecca Green & Trevor Williams
This study maps quantitative trait loci (QTL) for skeletal facial shape using a large sample of Diversity Outbred (DO) mice. We identified 37 facial shape QTL across 20 shape principal components (PCs) using a mixed effects regression that accounts for kinship among observations. The QTL include some previously identified intervals as well as new regions that expand the list of potential targets for future experimental study. Three QTL characterized shape associations with size (allometry). Median...
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