Histology and schematic overview of mouse soft palate development

Alexandre Grimaldi, Jingyuan Li, Pedro Sanchez, Richard Pelikan & Yang Chai
Orofacial clefting is the most common congenital craniofacial malformation affecting several distinct anatomical regions including the upper lip and hard and soft palate. Numerous studies revealed the etiology of orofacial clefting is complex involving genetic or environmental factors or their combination. Hence, it is essential to investigate the regulatory mechanisms of orofacial clefting. Our previous studies have suggested that humans and mice share similar orofacial development, anatomy and function, therefore, the mouse is an excellent...
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