Hallgrimsson, Marcucio. Developmental Nonlinearity Drives Phenotypic Robustness

Benedikt Hallgrimsson, Ralph Marcucio, David Katz, Trevor Williams, Charles Roseman, James Cheverud, Jennifer Fish & Rebecca Green
Robustness to perturbation is a fundamental feature of complex organisms. Mutations are the raw material for evolution, yet robustness to their effects is required for species survival. The mechanisms that produce robustness are poorly understood. Nonlinearities are a ubiquitous feature of development that may link variation in development to phenotypic robustness. Here, we manipulate the gene dosage of a signaling molecule, Fgf8, a critical regulator of vertebrate development. We demonstrate that variation in Fgf8 expression...
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