Activity of chimp neural crest enhancer near NARS2 in E11.5 transgenic mouse embryo – Tg(panTro4_chr11:76409267-76410157::LacZ).

Joanna Wysocka, Licia Selleri & Tomasz Swigut
Tg(panTro4_chr11:76409267-76410157::LacZ) chimp neural crest enhancer with activity in the periocular mesenchyme, mandibular prominence of the 1st branchial arch, 2nd branchial arch, proximal forelimb bud, and tail mesenchyme. This enhancer lacks the expression in the forebrain, midbrain, maxillary prominence of the 1st branchial arch, hindlimb bud and midgut, as well as decreased expression in the forelimb bud, somites, and 2nd branchial arch when compared with the equivalent human enhancer; this demonstrates a human species-specific bias when...
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